The six key research areas represented in the PhD program are oncology, neuroscience, immunology/infection, biomedical imaging, cardiovascular research, and molecular medicine. Students enrolled in the PhD program “Medical Life Science and Technology” have the opportunity to carry out their research project in one of the research groups affiliated with the Faculty of Medicine at TUM. Our faculty members are outstanding scientists and offer PhD projects - ranging from in vitro to in vivo, and to clinical research - in a stimulating research environment with cutting-edge technologies. The faculty members also provide the PhD students access to numerous excellent research consortia in the Munich area, which bring together a wide range of experimental expertise and know-how, to achieve a deeper understanding of complex biological processes, and of mechanisms of diseases. The research consortia include the prestigious Collaborative Research Centres (SFB), funded by the German Research Foundation, and the Clusters of the Excellence Initiative as well as the German Centers of Health Research (DZG).
2021
MLKL promotes cellular differentiation in myeloid leukemia by facilitating the release of G-CSF. Wang X, Ros U, Agrawal D, Keller EC, Slotta-Huspenina J, Dill V, Shen B, Shi R, Herold T, Belka C, Mishra R, Bassermann F, Garcia-Saez AJ, Jost PJ. Cell Death Differ. 2021.
Elimination of NF-κB signaling in Vimentin+ stromal cells attenuates tumorigenesis in a mouse model of Barrett's Esophagus. Anand A, Fang HY, Mohammad-Shahi D, Ingermann J, Baumeister T, Strangmann J, Schmid RM, Wang TC, Quante M. Carcinogenesis. 2021 Apr 17;42(3):405-413.
Anti-inflammatory chemoprevention attenuates the phenotype in a mouse model of esophageal adenocarcinoma. Baumeister T, Ingermann J, Marcazzan S, Fang HY, Oellinger R, Rad R, Engleitner T, Kleigrewe K, Anand A, Strangmann J, Schmid RM, Wang TC, Quante M. Carcinogenesis. 2021; 42:1068-1078.
Brief homogeneous TCR signals instruct common iNKT progenitors whose effector diversification is characterized by subsequent cytokine signaling. Bortoluzzi S, Dashtsoodol N, Engleitner T, Drees C, Helmrath S, Mir J, Toska A, Flossdorf M, Öllinger R, Solovey M, Colomé-Tatché M, Kalfaoglu B, Ono M, Buch T, Ammon T, Rad R, Schmidt-Supprian M. Immunity. 2021; 21: 1074-7613
T-cell engager antibodies enable T cells to control HBV infection and to target HBsAg-positive hepatoma in mice. Quitt O, Luo S, Meyer M, Xie Z, Golsaz-Shirazi F, Loffredo-Verde E, Festag J, Bockmann JH, Zhao L, Stadler D, Chou WM, Tedjokusumo R, Wettengel JM, Ko C, Noeßner E, Bulbuc N, Shokri F, Lüttgau S, Heikenwälder M, Bohne F, Moldenhauer G, Momburg F, Protzer U. J Hepatol. 2021; 75:1058-1071.
Mesenchymal Plasticity Regulated by Prrx1 Drives Aggressive Pancreatic Cancer Biology. Feldmann K, Maurer C, Peschke K, Teller S, Schuck K, Steiger K, Engleitner T, Öllinger R, Nomura A, Wirges N, Papargyriou A, Jahan Sarker RS, Ranjan RA, Dantes Z, Weichert W, Rustgi AK, Schmid RM, Rad R, Schneider G, Saur D, Reichert M. Gastroenterology. 2021; 160:346-361.
A Pancreas-Specific Ptf1a-Driven Cre Mouse Line Causes Paternally Transmitted Germline Recombination. Kabacaoğlu D, Ruess DA, Görgülü K, Steiger K, Lesina M, Algül H. Gastroenterology. 2021; 161:1695-1697.e4
Bcl3 Couples Cancer Stem Cell Enrichment With Pancreatic Cancer Molecular Subtypes. Ai J, Wörmann SM, Görgülü K, Vallespinos M, Zagorac S, Alcala S, Wu N, Kabacaoglu D, Berninger A, Navarro D, Kaya-Aksoy E, Ruess DA, Ciecielski KJ, Kowalska M, Demir IE, Ceyhan GO, Heid I, Braren R, Riemann M, Schreiner S, Hofmann S, Kutschke M, Jastroch M, Slotta-Huspenina J, Muckenhuber A, Schlitter AM, Schmid RM, Steiger K, Diakopoulos KN, Lesina M, Sainz B Jr, Algül H. Gastroenterology. 2021; 161:318-332.
Congenital heart disease risk loci identified by genome-wide association study in European patients. Lahm H, Jia M, Dreßen M, Wirth F, Puluca N, Gilsbach R, Keavney BD, Cleuziou J, Beck N, Bondareva O, Dzilic E, Burri M, König KC, Ziegelmüller JA, Abou-Ajram C, Neb I, Zhang Z, Doppler SA, Mastantuono E, Lichtner P, Eckstein G, Hörer J, Ewert P, Priest JR, Hein L, Lange R, Meitinger T, Cordell HJ, Müller-Myhsok B, Krane M. J Clin Invest. 2021; 131:e141837.
Deep learning boosts sensitivity of mass spectrometry-based immunopeptidomics. Wilhelm M, Zolg DP, Graber M, Gessulat S, Schmidt T, Schnatbaum K, Schwencke-Westphal C, Seifert P, de Andrade Krätzig N, Zerweck J, Knaute T, Bräunlein E, Samaras P, Lautenbacher L, Klaeger S, Wenschuh H, Rad R, Delanghe B, Huhmer A, Carr SA, Clauser KR, Krackhardt AM, Reimer U, Kuster B. Nat Commun. 2021; 12:3346.
Completion of neuronal remodeling prompts myelination along developing motor axon branches. Wang M, Kleele T, Xiao Y, Plucinska G, Avramopoulos P, Engelhardt S, Schwab MH, Kneussel M, Czopka T, Sherman DL, Brophy PJ, Misgeld T, Brill MS. J Cell Biol. 2021; 220: e201911114.
Sequential Defects in Cardiac Lineage Commitment and Maturation Cause Hypoplastic Left Heart Syndrome. Krane M, Dreßen M, Santamaria G, My I, Schneider CM, Dorn T, Laue S, Mastantuono E, Berutti R, Rawat H, Gilsbach R, Schneider P, Lahm H, Schwarz S, Doppler SA, Paige S, Puluca N, Doll S, Neb I, Brade T, Zhang Z, Abou-Ajram C, Northoff B, Holdt LM, Sudhop S, Sahara M, Goedel A, Dendorfer A, Tjong FVY, Rijlaarsdam ME, Cleuziou J, Lang N, Kupatt C, Bezzina C, Lange R, Bowles NE, Mann M, Gelb BD, Crotti L, Hein L, Meitinger T, Wu S, Sinnecker D, Gruber PJ, Laugwitz KL, Moretti A. Circulation. 2021; 144:1409-1428.
2020
Frontoparietal and salience network alterations in obsessive–compulsive disorder: insights from independent component and sliding time window analyses.
Gürsel DA, Reinholz L, Bremer B, Schmitz-Koep B, Franzmeier N, Avram M, Koch K.
J Psychiatry Neurosci. 2020 May 1;45(3):214-221. doi: 10.1503/jpn.190038.
Quantitation of norovirus-specific IgG before and after infection in immunocompromised patients.
Afridi SQ, Moeini H, Kalali B, Wettengel JM, Quitt O, Semper R, Gerhard M, Protzer U, Hoffmann D.
Braz J Microbiol. 2020 Mar;51(1):183-187. doi: 10.1007/s42770-019-00176-1.
Hypoxia and the hypoxia inducible factor 1α activate protein kinase A by repressing RII beta subunit transcription.
Lucia K, Wu Y, Garcia JM, Barlier A, Buchfelder M, Saeger W, Renner U, Stalla GK, Theodoropoulou M.
Oncogene. 2020 Apr;39(16):3367-3380. doi: 10.1038/s41388-020-1223-6.
MCL-1 gains occur with high frequency in lung adenocarcinoma and can be targeted therapeutically. Munkhbaatar E, Dietzen M, Agrawal D, Anton M, Jesinghaus M, Boxberg M, Pfarr N, Bidola P, Uhrig S, Höckendorf U, Meinhardt AL, Wahida A, Heid I, Braren R, Mishra R, Warth A, Muley T, Poh PSP, Wang X, Fröhling S, Steiger K, Slotta-Huspenina J, van Griensven M, Pfeiffer F, Lange S, Rad R, Spella M, Stathopoulos GT, Ruland J, Bassermann F, Weichert W, Strasser A, Branca C, Heikenwalder M, Swanton C, McGranahan N, Jost PJ. Nat Commun. 2020; 11:4527.
Notch Signaling Mediates Differentiation in Barrett's Esophagus and Promotes Progression to Adenocarcinoma. Kunze B, Wein F, Fang HY, Anand A, Baumeister T, Strangmann J, Gerland S, Ingermann J, Münch NS, Wiethaler M, Sahm V, Hidalgo-Sastre A, Lange S, Lightdale CJ, Bokhari A, Falk GW, Friedman RA, Ginsberg GG, Iyer PG, Jin Z, Nakagawa H, Shawber CJ, Nguyen T, Raab WJ, Dalerba P, Rustgi AK, Sepulveda AR, Wang KK, Schmid RM, Wang TC, Abrams JA, Quante M. Gastroenterology. 2020; 159:575-590.
Aberrant striatal dopamine links topographically with cortico-thalamic dysconnectivity in schizophrenia. Avram M, Brandl F, Knolle F, Cabello J, Leucht C, Scherr M, Mustafa M, Koutsouleris N, Leucht S, Ziegler S, Sorg C. Brain. 2020; 143:3495-3505.
Salt generates antiinflammatory Th17 cells but amplifies pathogenicity in proinflammatory cytokine microenvironments. Matthias J, Heink S, Picard F, Zeiträg J, Kolz A, Chao YY, Soll D, de Almeida GP, Glasmacher E, Jacobsen ID, Riedel T, Peters A, Floess S, Huehn J, Baumjohann D, Huber M, Korn T, Zielinski CE. J Clin Invest. 2020; 130:4587-4600.
Implementing cell-free DNA of pancreatic cancer patient-derived organoids for personalized oncology. Dantes Z, Yen HY, Pfarr N, Winter C, Steiger K, Muckenhuber A, Hennig A, Lange S, Engleitner T, Öllinger R, Maresch R, Orben F, Heid I, Kaissis G, Shi K, Topping G, Stögbauer F, Wirth M, Peschke K, Papargyriou A, Rezaee-Oghazi M, Feldmann K, Schäfer AP, Ranjan R, Lubeseder-Martellato C, Stange DE, Welsch T, Martignoni M, Ceyhan GO, Friess H, Herner A, Liotta L, Treiber M, von Figura G, Abdelhafez M, Klare P, Schlag C, Algül H, Siveke J, Braren R, Weirich G, Weichert W, Saur D, Rad R, Schmid RM, Schneider G, Reichert M. JCI Insight. 2020; 5:e137809.
Functionally distinct subgroups of oligodendrocyte precursor cells integrate neural activity and execute myelin formation. Marisca R, Hoche T, Agirre E, Hoodless LJ, Barkey W, Auer F, Castelo-Branco G, Czopka T. Nat Neurosci. 2020; 23:363-374.
AKT-dependent NOTCH3 activation drives tumor progression in a model of mesenchymal colorectal cancer. Varga J, Nicolas A, Petrocelli V, Pesic M, Mahmoud A, Michels BE, Etlioglu E, Yepes D, Häupl B, Ziegler PK, Bankov K, Wild PJ, Wanninger S, Medyouf H, Farin HF, Tejpar S, Oellerich T, Ruland J, Siebel CW, Greten FR. J Exp Med. 2020; 217:e20191515.
Knockdown of Virus Antigen Expression Increases Therapeutic Vaccine Efficacy in High-Titer Hepatitis B Virus Carrier Mice. Michler T, Kosinska AD, Festag J, Bunse T, Su J, Ringelhan M, Imhof H, Grimm D, Steiger K, Mogler C, Heikenwalder M, Michel ML, Guzman CA, Milstein S, Sepp-Lorenzino L, Knolle P, Protzer U. Gastroenterology. 2020; 158:1762-1775.
Pushing the boundaries of optoacoustic microscopy by total impulse response characterization. Seeger M, Soliman D, Aguirre J, Diot G, Wierzbowski J, Ntziachristos V. Nat Commun. 2020; 11:2910.
The physiological effects of noninvasive brain stimulation fundamentally differ across the human cortex. Castrillon G, Sollmann N, Kurcyus K, Razi A, Krieg SM, Riedl V. Sci Adv. 2020; 6:eaay2739.
The physiological effects of noninvasive brain stimulation fundamentally differ across the human cortex. Castrillon G, Sollmann N, Kurcyus K, Razi A, Krieg SM, Riedl V. Sci Adv. 2020; 6:eaay2739.
2019
Brain dysfunction in chronic pain patients assessed by resting-state electroencephalography.
Ta Dinh S, Nickel MM, Tiemann L, May ES, Heitmann H, Hohn VD, Edenharter G, Utpadel-Fischler D, Tölle TR, Sauseng P, Gross J, Ploner M.
Pain. 2019 Dec;160(12):2751-2765. doi: 10.1097/j.pain.0000000000001666.
Cognitive reward control recruits medial and lateral frontal cortices, which are also involved in cognitive emotion regulation: A coordinate-based meta-analysis of fMRI studies.
Brandl F, Le Houcq Corbi Z, Mulej Bratec S, Sorg C.
Neuroimage. 2019 Oct 15;200:659-673. doi: 10.1016/j.neuroimage.2019.07.008.
Qualitative and quantitative neointimal characterization by optical coherence tomography in patients presenting with in-stent restenosis.
Xhepa E, Byrne RA, Rivero F, Rroku A, Cuesta J, Ndrepepa G, Kufner S, Valiente TB, Cassese S, Garcia-Guimaraes M, Lahmann AL, Rai H, Schunkert H, Joner M, Pérez-Vizcayno MJ, Gonzalo N, Alfonso F, Kastrati A.
Clin Res Cardiol. 2019 Sep;108(9):1059-1068. doi: 10.1007/s00392-019-01439-5.
Frequency-Dependent Spatial Distribution of Functional Hubs in the Human Brain and Alterations in Major Depressive Disorder.
Ries A, Hollander M, Glim S, Meng C, Sorg C, Wohlschläger A.
Front Hum Neurosci. 2019 May 14;13:146. doi: 10.3389/fnhum.2019.00146.
Evaluation of a Fully Human, Hepatitis B Virus-Specific Chimeric Antigen Receptor in an Immunocompetent Mouse Model.
Festag MM, Festag J, Fräßle SP, Asen T, Sacherl J, Schreiber S, Mück-Häusl MA, Busch DH, Wisskirchen K, Protzer U.
Mol Ther. 2019 May 8;27(5):947-959. doi: 10.1016/j.ymthe.2019.02.001.
What Makes a pDC: Recent Advances in Understanding Plasmacytoid DC Development and Heterogeneity.
Musumeci A, Lutz K, Winheim E, Krug AB.
Front Immunol. 2019 May 29;10:1222. doi: 10.3389/fimmu.2019.01222.
An Improved, Chemically Modified RNA Encoding BMP-2 Enhances Osteogenesis In Vitro and In Vivo.
Zhang W, De La Vega RE, Coenen MJ, Müller SA, Peniche Silva CJ, Aneja MK, Plank C, van Griensven M, Evans CH, Balmayor ER.
Tissue Eng Part A. 2019 Jan;25(1-2):131-144. doi: 10.1089/ten.
High-Fat Diet Accelerates Carcinogenesis in a Mouse Model of Barrett's Esophagus via Interleukin 8 and Alterations to the Gut Microbiome. Münch NS, Fang HY, Ingermann J, Maurer HC, Anand A, Kellner V, Sahm V, Wiethaler M, Baumeister T, Wein F, Einwächter H, Bolze F, Klingenspor M, Haller D, Kavanagh M, Lysaght J, Friedman R, Dannenberg AJ, Pollak M, Holt PR, Muthupalani S, Fox JG, Whary MT, Lee Y, Ren TY, Elliot R, Fitzgerald R, Steiger K, Schmid RM, Wang TC, Quante M. Gastroenterology. 2019; 157:492-506.
Ticagrelor or Prasugrel in Patients with Acute Coronary Syndromes. Schüpke S, Neumann FJ, Menichelli M, Mayer K, Bernlochner I, Wöhrle J, Richardt G, Liebetrau C, Witzenbichler B, Antoniucci D, Akin I, Bott-Flügel L, Fischer M, Landmesser U, Katus HA, Sibbing D, Seyfarth M, Janisch M, Boncompagni D, Hilz R, Rottbauer W, Okrojek R, Möllmann H, Hochholzer W, Migliorini A, Cassese S, Mollo P, Xhepa E, Kufner S, Strehle A, Leggewie S, Allali A, Ndrepepa G, Schühlen H, Angiolillo DJ, Hamm CW, Hapfelmeier A, Tölg R, Trenk D, Schunkert H, Laugwitz KL, Kastrati A; ISAR-REACT 5 Trial Investigators. N Engl J Med. 2019; 381:1524-1534.
Specific Substantial Dysconnectivity in Schizophrenia: A Transdiagnostic Multimodal Meta-analysis of Resting-State Functional and Structural Magnetic Resonance Imaging Studies. Brandl F, Avram M, Weise B, Shang J, Simões B, Bertram T, Hoffmann Ayala D, Penzel N, Gürsel DA, Bäuml J, Wohlschläger AM, Vukadinovic Z, Koutsouleris N, Leucht S, Sorg C. Biol Psychiatry. 2019; 85:573-583.
Reduced striatal dopamine synthesis capacity in patients with schizophrenia during remission of positive symptoms. Avram M, Brandl F, Cabello J, Leucht C, Scherr M, Mustafa M, Leucht S, Ziegler S, Sorg C. Brain. 2019; 142:1813-1826.
A vicious cycle of β amyloid-dependent neuronal hyperactivation. Zott B, Simon MM, Hong W, Unger F, Chen-Engerer HJ, Frosch MP, Sakmann B, Walsh DM, Konnerth A. Science. 2019; 365, 6453:559-565.
Sodium chloride is an ionic checkpoint for human TH2 cells and shapes the atopic skin microenvironment. Matthias J, Maul J, Noster R, Meinl H, Chao YY, Gerstenberg H, Jeschke F, Gasparoni G, Welle A, Walter J, Nordström K, Eberhardt K, Renisch D, Donakonda S, Knolle P, Soll D, Grabbe S, Garzorz-Stark N, Eyerich K, Biedermann T, Baumjohann D, Zielinski CE. Sci Transl Med. 2019; 11:eaau0683.
Levels of the Autophagy-Related 5 Protein Affect Progression and Metastasis of Pancreatic Tumors in Mice. Görgülü K, Diakopoulos KN, Ai J, Schoeps B, Kabacaoglu D, Karpathaki AF, Ciecielski KJ, Kaya-Aksoy E, Ruess DA, Berninger A, Kowalska M, Stevanovic M, Wörmann SM, Wartmann T, Zhao Y, Halangk W, Voronina S, Tepikin A, Schlitter AM, Steiger K, Artati A, Adamski J, Aichler M, Walch A, Jastroch M, Hartleben G, Mantzoros CS, Weichert W, Schmid RM, Herzig S, Krüger A, Sainz B Jr, Lesina M, Algül H. Gastroenterology. 2019; 156:203-217.
PD-1 Tumor Suppressor Signaling in T Cell Lymphomas. Wartewig T, Ruland J. Trends Immunol. 2019; 40:403-414.
The uric acid crystal receptor Clec12A potentiates type I interferon responses. Li K, Neumann K, Duhan V, Namineni S, Hansen AL, Wartewig T, Kurgyis Z, Holm CK, Heikenwalder M, Lang KS, Ruland J. Proc Natl Acad Sci U S A. 2019; 116:18544-18549.
Concomitant Infection of S. mansoni and H. pylori Promotes Promiscuity of Antigen-Experienced Cells and Primes the Liver for a Lower Fibrotic Response. Bhattacharjee S, Mejías-Luque R, Loffredo-Verde E, Toska A, Flossdorf M, Gerhard M, Prazeres da Costa C. Cell Rep. 2019; 28:231-244.e5.
High-performance calcium sensors for imaging activity in neuronal populations and microcompartments. Dana H, Sun Y, Mohar B, Hulse BK, Kerlin AM, Hasseman JP, Tsegaye G, Tsang A, Wong A, Patel R, Macklin JJ, Chen Y, Konnerth A, Jayaraman V, Looger LL, Schreiter ER, Svoboda K, Kim DS. Nat Methods. 2019; 16:649-657.
Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation. Jordão MJC, Sankowski R, Brendecke SM, Sagar, Locatelli G, Tai YH, Tay TL, Schramm E, Armbruster S, Hagemeyer N, Groß O, Mai D, Çiçek Ö, Falk T, Kerschensteiner M, Grün D, Prinz M. Science. 2019; 363:eaat7554.
Long-term in vivo microscopy of CAR T cell dynamics during eradication of CNS lymphoma in
mice. Mulazzani M, Fräßle SP, von Mücke-Heim I, Langer S, Zhou X, Ishikawa-Ankerhold H, Leube
J, Zhang W, Dötsch S, Svec M, Rudelius M, Dreyling M, von Bergwelt-Baildon M, Straube A,
Buchholz VR, Busch DH, von Baumgarten L. Proc Natl Acad Sci U S A. 2019; 116:24275-24284.
Two types of functionally distinct Ca2+ stores in hippocampal neurons. Chen-Engerer HJ, Hartmann J, Karl RM, Yang J, Feske S, Konnerth A. Nat Commun. 2019; 10:3223.
2018
Type I Immune Response Induces Keratinocyte Necroptosis and Is Associated with Interface Dermatitis.
Lauffer F, Jargosch M, Krause L, Garzorz-Stark N, Franz R, Roenneberg S, Böhner A, Mueller NS, Theis FJ, Schmidt-Weber CB, Biedermann T, Eyerich S, Eyerich K.
J Invest Dermatol. 2018 Aug;138(8):1785-1794. doi: 10.1016/j.jid.2018.02.034.
IL-22 sustains epithelial integrity in progressive kidney remodeling and fibrosis.
Weidenbusch M, Song S, Iwakura T, Shi C, Rodler S, Kobold S, Mulay SR, Honarpisheh MM, Anders HJ.
Physiol Rep. 2018 Aug;6(16):e13817. doi: 10.14814/phy2.13817.
Clinical, biochemical and genetic spectrum of 70 patients with ACAD9 deficiency: is riboflavin supplementation effective?
Repp BM, Mastantuono E, Alston CL, Schiff M, Haack TB, Rötig A, Ardissone A, Lombès A, Catarino CB, Diodato D, Schottmann G, Poulton J, Burlina A, Jonckheere A, Munnich A, Rolinski B, Ghezzi D, Rokicki D, Wellesley D, Martinelli D, Wenhong D, Lamantea E, Ostergaard E, Pronicka E, Pierre G, Smeets HJM, Wittig I, Scurr I, de Coo IFM, Moroni I, Smet J, Mayr JA, Dai L, de Meirleir L, Schuelke M, Zeviani M, Morscher RJ, McFarland R, Seneca S, Klopstock T, Meitinger T, Wieland T, Strom TM, Herberg U, Ahting U, Sperl W, Nassogne MC, Ling H, Fang F, Freisinger P, Van Coster R, Strecker V, Taylor RW, Häberle J, Vockley J, Prokisch H, Wortmann S.
Orphanet J Rare Dis. 2018 Jul 19;13(1):120. doi: 10.1186/s13023-018-0784-8.
Impact of generalized anxiety disorder (GAD) on prehospital delay of acute myocardial infarction patients. Findings from the multicenter MEDEA study.
Fang XY, Spieler D, Albarqouni L, Ronel J, Ladwig KH.
Clin Res Cardiol. 2018 Jun;107(6):471-478. doi: 10.1007/s00392-018-1208-4.
Aldehyde dehydrogenase 1A3 (ALDH1A3) is regulated by autophagy in human glioblastoma cells.
Wu W, Schecker J, Würstle S, Schneider F, Schönfelder M, Schlegel J.
Cancer Lett. 2018 Mar 28;417:112-123. doi: 10.1016/j.canlet.2017.12.036. Epub 2018 Jan 3.
Calcium Sensor for Photoacoustic Imaging.
Roberts S, Seeger M, Jiang Y, Mishra A, Sigmund F, Stelzl A, Lauri A, Symvoulidis P, Rolbieski H, Preller M, Deán-Ben XL, Razansky D, Orschmann T, Desbordes SC, Vetschera P, Bach T, Ntziachristos V, Westmeyer GG.
J Am Chem Soc. 2018 Feb 28;140(8):2718-2721. doi: 10.1021/jacs.7b03064.
Hepatitis B virus genome recycling and de novo secondary infection events maintain stable cccDNA levels. Ko C, Chakraborty A, Chou WM, Hasreiter J, Wettengel JM, Stadler D, Bester R, Asen T, Zhang K, Wisskirchen K, McKeating JA, Ryu WS, Protzer U. J Hepatol. 2018; 69:1231-1241.
Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase. Ruess DA, Heynen GJ, Ciecielski KJ, Ai J, Berninger A, Kabacaoglu D, Görgülü K, Dantes Z, Wörmann SM, Diakopoulos KN, Karpathaki AF, Kowalska M, Kaya-Aksoy E, Song L, van der Laan EAZ, López-Alberca MP, Nazaré M, Reichert M, Saur D, Erkan MM, Hopt UT, Sainz B Jr, Birchmeier W, Schmid RM, Lesina M, Algül H. Nat Med. 2018; 24:954-960.
What Happens with the Circuit in Alzheimer's Disease in Mice and Humans? Zott B, Busche MA, Sperling RA, Konnerth A. Annu Rev Neurosci. 2018; 41:277-297.
Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis. Ziegler PK, Bollrath J, Pallangyo CK, Matsutani T, Canli Ö, De Oliveira T, Diamanti MA, Müller N, Gamrekelashvili J, Putoczki T, Horst D, Mankan AK, Öner MG, Müller S, Müller-Höcker J, Kirchner T, Slotta-Huspenina J, Taketo MM, Reinheckel T, Dröse S, Larner AC, Wels WS, Ernst M, Greten TF, Arkan MC, Korn T, Wirth D, Greten FR. Cell. 2018; 174:88-101.
Mononuclear phagocytes locally specify and adapt their phenotype in a multiple sclerosis model. Locatelli G, Theodorou D, Kendirli A, Jordão MJC, Staszewski O, Phulphagar K, Cantuti-Castelvetri L, Dagkalis A, Bessis A, Simons M, Meissner F, Prinz M, Kerschensteiner M. Nat Neurosci. 2018; 21:1196-1208.
Non-cell-autonomous function of DR6 in Schwann cell proliferation. Colombo A, Hsia HE, Wang M, Kuhn PH, Brill MS, Canevazzi P, Feederle R, Taveggia C, Misgeld T, Lichtenthaler SF. EMBO J. 2018; 37:e97390.
Distinct patterns of brain activity mediate perceptual and motor and autonomic responses to noxious stimuli. Tiemann L, Hohn VD, Ta Dinh S, May ES, Nickel MM, Gross J, Ploner M. Nat Commun. 2018; 9:4487.
Calcium Sensor for Photoacoustic Imaging. Roberts S, Seeger M, Jiang Y, Mishra A, Sigmund F, Stelzl A, Lauri A, Symvoulidis P, Rolbieski H, Preller M, Deán-Ben XL, Razansky D, Orschmann T, Desbordes SC, Vetschera P, Bach T, Ntziachristos V, Westmeyer GG. J Am Chem Soc. 2018; 140:2718-2721.
β2 Adrenergic-Neurotrophin Feedforward Loop Promotes Pancreatic Cancer. Renz BW, Takahashi R, Tanaka T, Macchini M, Hayakawa Y, Dantes Z, Maurer HC, Chen X, Jiang Z, Westphalen CB, Ilmer M, Valenti G, Mohanta SK, Habenicht AJR, Middelhoff M, Chu T, Nagar K, Tailor Y, Casadei R, Di Marco M, Kleespies A, Friedman RA, Remotti H, Reichert M, Worthley DL, Neumann J, Werner J, Iuga AC, Olive KP, Wang TC. Cancer Cell. 2018; 33:75-90.
Rate of β-amyloid accumulation varies with baseline amyloid burden: Implications for anti-amyloid drug trials. Guo T, Dukart J, Brendel M, Rominger A, Grimmer T, Yakushev I; Alzheimer's Disease Neuroimaging Initiative. Alzheimers Dement. 2018; 14:1387-1396
Interplay of cell-cell contacts and RhoA/MRTF-A signaling regulates cardiomyocyte identity. Dorn T, Kornherr J, Parrotta EI, Zawada D, Ayetey H, Santamaria G, Iop L, Mastantuono E, Sinnecker D, Goedel A, Dirschinger RJ, My I, Laue S, Bozoglu T, Baarlink C, Ziegler T, Graf E, Hinkel R, Cuda G, Kääb S, Grace AA, Grosse R, Kupatt C, Meitinger T, Smith AG, Laugwitz KL, Moretti A. EMBO J. 2018; 37:e98133.
Opposite Dynamics of GABA and Glutamate Levels in the Occipital Cortex during Visual
Processing. Kurcyus K, Annac E, Hanning NM, Harris AD, Oeltzschner G, Edden R, Riedl V.
J Neurosci. 2018;38:9967-9976.
2017
Influence of pain on motor preparation in the human brain.
Postorino M, May ES, Nickel MM, Tiemann L, Ploner M.
J Neurophysiol. 2017 Oct 1;118(4):2267-2274. doi: 10.1152/jn.00489.2017.
The AMP-Related Kinase (AMPK) Induces Ca2+-Independent Dilation of Resistance Arteries by Interfering With Actin Filament Formation.
Schubert KM, Qiu J, Blodow S, Wiedenmann M, Lubomirov LT, Pfitzer G, Pohl U, Schneider H.
Circ Res. 2017 Jul 7;121(2):149-161. doi: 10.1161/CIRCRESAHA.116.309962.
Potential accuracy of navigated K-wire guided supra-acetabular osteotomies in orthopedic surgery: a CT fluoroscopy cadaver study.
Postl LK, Kirchhoff C, Toepfer A, Kirchhoff S, Schmitt-Sody M, von Eisenhart-Rothe R, Burgkart R.
Int J Med Robot. 2017 Jun;13(2). doi: 10.1002/rcs.1752.
Two serines in the distal C-terminus of the human ß1-adrenoceptor determine ß-arrestin2 recruitment.
Hinz L, Ahles A, Ruprecht B, Küster B, Engelhardt S.
PLoS One. 2017 May 4;12(5):e0176450. doi: 10.1371/journal.pone.0176450.
Predicting Regional Pattern of Longitudinal β-Amyloid Accumulation by Baseline PET.
Guo T, Brendel M, Grimmer T, Rominger A, Yakushev I; Alzheimer’s Disease Neuroimaging Initiative.
J Nucl Med. 2017 Apr;58(4):639-645. doi: 10.2967/jnumed.116.176115.
Interhemispheric connectivity revealed by diffusion tensor imaging fiber tracking derived from navigated transcranial magnetic stimulation maps as a sign of language function at risk in patients with brain tumors.
Sollmann N, Negwer C, Tussis L, Hauck T, Ille S, Maurer S, Giglhuber K, Bauer JS, Ringel F, Meyer B, Krieg SM.
J Neurosurg. 2017 Jan;126(1):222-233. doi: 10.3171/2016.1.JNS152053. Epub 2016 Apr 1.
Roquin Paralogs Differentially Regulate Functional NKT Cell Subsets. Drees C, Vahl JC, Bortoluzzi S, Heger KD, Fischer JC, Wunderlich FT, Peschel C, Schmidt-Supprian M. J Immunol. 2017; 198:2747-2759.
Tools to define the melanoma-associated immunopeptidome. Bräunlein E, Krackhardt AM. Immunology. 2017; 152:536-544.
The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity. Schneider KS, Groß CJ, Dreier RF, Saller BS, Mishra R, Gorka O, Heilig R, Meunier E, Dick MS, Ćiković T, Sodenkamp J, Médard G, Naumann R, Ruland J, Kuster B, Broz P, Groß O. Cell Rep. 2017; 21:3846-3859.
BACE inhibition-dependent repair of Alzheimer's pathophysiology. Keskin AD, Kekuš M, Adelsberger H, Neumann U, Shimshek DR, Song B, Zott B, Peng T, Förstl H, Staufenbiel M, Nelken I, Sakmann B, Konnerth A, Busche MA. Proc Natl Acad Sci U S A. 2017; 114, 32:8631-8636.
PD-1 is a haploinsufficient suppressor of T cell lymphomagenesis. Wartewig T, Kurgyis Z, Keppler S, Pechloff K, Hameister E, Öllinger R, Maresch R, Buch T, Steiger K, Winter C, Rad R, Ruland J. Nature. 2017; 552, 7683:121-125.
2016
Vav Proteins Are Key Regulators of Card9 Signaling for Innate Antifungal Immunity.
Roth S, Bergmann H, Jaeger M, Yeroslaviz A, Neumann K, Koenig PA, Prazeres da Costa C, Vanes L, Kumar V, Johnson M, Menacho-Márquez M, Habermann B, Tybulewicz VL, Netea M, Bustelo XR, Ruland J.
Cell Rep. 2016 Dec 6;17(10):2572-2583. doi: 10.1016/j.celrep.2016.11.018.
Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry.
Bassani-Sternberg M, Bräunlein E, Klar R, Engleitner T, Sinitcyn P, Audehm S, Straub M, Weber J, Slotta-Huspenina J, Specht K, Martignoni ME, Werner A, Hein R, H Busch D, Peschel C, Rad R, Cox J, Mann M, Krackhardt AM.
Nat Commun. 2016 Nov 21;7:13404. doi: 10.1038/ncomms13404.
2015
Combining microscopy with mesoscopy using optical and optoacoustic label-free modes.
Soliman D, Tserevelakis GJ, Omar M, Ntziachristos V.
Sci Rep. 2015 Aug 26;5:12902. doi: 10.1038/srep12902.
Hydrogels for Engineering of Perfusable Vascular Networks.
Liu J, Zheng H, Poh PS, Machens HG, Schilling AF.
Int J Mol Sci. 2015 Jul 14;16(7):15997-6016. doi: 10.3390/ijms160715997.